When Ad-REIC formulation is administered into cancer cells, forced expression of REIC gene leads to accumulation of unfolded REIC proteins inside the cells, and eventually the cancer cells will self-destroy (Apoptosis) due to endoplasmic reticulum stress.
1Difference between normal cells and cancer cells
2Mechanism of apoptosis of cancer cells by Ad-REIC formulation
3Mechanism of cell destruction of metastasized cancer cells
By administering Ad-REIC formulation, cancer immunity is activated, and cancer cells not directly administered the drug (metastatic cancer) are also attacked and repelled.